| Aug 27, 2024 |
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(Nanowerk Information) VTT has developed a pores and skin spray, based mostly on nanocellulose and antimicrobial compounds from wild berries, which can be utilized to deal with wounds and get rid of hospital-acquired micro organism equivalent to MRSA earlier than surgical procedure. The product can be utilized as a cream, transdermal patch or wound dressing.
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“The fast-acting surgical spray and efficacious dressing are based mostly on a producing course of now we have developed, the place the floor and pores of a nanocellulose movie are impregnated with a berry extract in order that the antimicrobial compounds don’t get trapped contained in the fibre community. VTT has greater than 15 years of expertise within the laboratory-scale and pilot-scale manufacturing of nanocellulose gels and movies”, says Panu Lahtinen, a Senior Scientist at VTT.
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The following step for the berry extract, which is produced utilizing VTT InnoBerry Applied sciences™ manufacturing technique, is to seek out corporations interested by growing, producing and commercialising the merchandise, to allow them to be launched onto the market within the subsequent few years.
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In nature, berry compounds defend the seed
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The floor of berry seeds is wealthy in antimicrobial compounds, so berry extracts are helpful for meals, beauty and medical purposes. The function of those compounds in nature is to guard the seed from microbes equivalent to moulds earlier than germination, however they will additionally assist forestall the expansion of harmful microbes on human pores and skin. Even a tiny quantity of berry extract can kill pathogenic micro organism equivalent to MRSA with out harming the pores and skin’s helpful microbiota.
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Berries are used to make juice, however important portions of press cake stay as a by-product after processing. This press cake comprises the berry pores and skin and seeds, that are wealthy in antimicrobial compounds. VTT has developed applied sciences to generate press-cake extracts enriched with these compounds, or to provide the important thing molecules in cultivated plant cells utilizing plant biotechnology, which permits year-round manufacturing unaffected by variations within the berry harvest.
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For greater than 20 years, VTT has been learning the well being advantages of arctic berries and their antimicrobial properties. These research have proven that berries comprise antimicrobial phenolic compounds, equivalent to ellagitannins, that kill pathogenic micro organism successfully. Such compounds will be recovered from the press cake utilizing VTT’s patented dry and moist fractionation applied sciences adopted by environmentally pleasant hydrothermal extraction with out using dangerous solvents.
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The berry extract developed by VTT can even substitute using artificial preservatives in cosmetics and nanosilver formulations in wound-care merchandise.
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“Our analysis has recognized antimicrobial compounds in a number of wild berries, together with sea buckthorn, bilberry, strawberry, cloudberry, lingonberry and raspberry. Massive-scale manufacturing is best to realize from raspberry as a result of there’s enough uncooked materials. To course of the seeds, it’s essential to discover a firm that’s skilled on this job within the worth chain,” says Kirsi-Marja Oksman-Caldentey, Affiliate Professor and Senior Advisor at VTT.
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Scientific references
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Pure antimicrobials from cloudberry (Rubus chamaemorus) seeds by sanding and hydrothermal extraction. ACS Meals Sci. Technol.
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Discount of methicillin-resistant Staphylococcus aureus biofilm progress and improvement by arctic berry extracts. Entrance. Cell. Infect. Microbiol.
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Sanguiin H-6 fractionated from cloudberry (Rubus chamaemorus) seeds can forestall the methicillin-resistant Staphylococcus aureus biofilm improvement throughout wound an infection. Antibiotics
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