Thermosensitive hydrogel as a sustained launch provider for mesenchymal stem cell-derived extracellular vesicles within the remedy of intrauterine adhesion | Journal of Nanobiotechnology

  • Yu D, Wong YM, Cheong Y, Xia E, Li TC. Asherman syndrome–one century later. Fertil Steril. 2008;89:759–79.

    Article 
    PubMed 

    Google Scholar
     

  • Lee WL, Liu CH, Cheng M, Chang WH, Liu WM, Wang PH. Deal with the Major Prevention of Intrauterine Adhesions: present Idea and Imaginative and prescient. Int J Mol Sci 2021, 22.

  • Gargett CE, Nguyen HP, Ye L. Endometrial regeneration and endometrial stem/progenitor cells. Rev Endocr Metab Disord. 2012;13:235–51.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Salma U, Xue M, Ali Sheikh MS, Guan X, Xu B, Zhang A, et al. Position of reworking progress factor-beta1 and smads signaling pathway in intrauterine adhesion. Mediators Inflamm. 2016;2016:4158287.

  • Ang CJ, Skokan TD, McKinley KL. Mechanisms of regeneration and fibrosis within the Endometrium. Annu Rev Cell Dev Biol. 2023;39:197–221.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Ma J, Zhan H, Li W, Zhang L, Yun F, Wu R, Lin J, Li Y. Latest traits in therapeutic methods for repairing endometrial tissue in intrauterine adhesion. Biomater Res. 2021;25:40.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Raposo G, Stahl PD. Extracellular vesicles: a brand new communication paradigm? Nat Rev Mol Cell Biol. 2019;20:509–10.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Kalluri R, LeBleu VS. The biology, operate, and biomedical functions of exosomes. Science 2020, 367.

  • An Y, Lin S, Tan X, Zhu S, Nie F, Zhen Y, Gu L, Zhang C, Wang B, Wei W, et al. Exosomes from adipose-derived stem cells and utility to pores and skin wound therapeutic. Cell Prolif. 2021;54:e12993.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Abbaszadeh H, Ghorbani F, Derakhshani M, Movassaghpour A, Yousefi M. Human umbilical twine mesenchymal stem cell-derived extracellular vesicles: a novel therapeutic paradigm. J Cell Physiol. 2020;235:706–17.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Kou M, Huang L, Yang J, Chiang Z, Chen S, Liu J, Guo L, Zhang X, Zhou X, Xu X, et al. Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a subsequent technology therapeutic software? Cell Loss of life Dis. 2022;13:580.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Yaghoubi Y, Movassaghpour A, Zamani M, Talebi M, Mehdizadeh A, Yousefi M. Human umbilical twine mesenchymal stem cells derived-exosomes in illnesses remedy. Life Sci. 2019;233:116733.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Li Ok, Yan G, Huang H, Zheng M, Ma Ok, Cui X, Lu D, Zheng L, Zhu B, Cheng J, Zhao J. Anti-inflammatory and immunomodulatory results of the extracellular vesicles derived from human umbilical twine mesenchymal stem cells on osteoarthritis through M2 macrophages. J Nanobiotechnol. 2022;20:38.

    Article 
    CAS 

    Google Scholar
     

  • Xin L, Lin X, Zhou F, Li C, Wang X, Yu H, Pan Y, Fei H, Ma L, Zhang S. A scaffold laden with mesenchymal stem cell-derived exosomes for selling endometrium regeneration and fertility restoration via macrophage immunomodulation. Acta Biomater. 2020;113:252–66.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Zhang Y, Hao Z, Wang P, Xia Y, Wu J, Xia D, Fang S, Xu S. Exosomes from human umbilical twine mesenchymal stem cells improve fracture therapeutic via HIF-1alpha-mediated promotion of angiogenesis in a rat mannequin of stabilized fracture. Cell Prolif. 2019;52:e12570.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tan SH, Chua DAC, Tang JRJ, Bonnard C, Leavesley D, Liang Ok. Design of hydrogel-based scaffolds for in vitro three-dimensional human pores and skin mannequin reconstruction. Acta Biomater. 2022;153:13–37.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Liang Y, He J, Guo B. Purposeful hydrogels as Wound Dressing to Improve Wound Therapeutic. ACS Nano. 2021;15:12687–722.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Yu H, Gao R, Liu Y, Fu L, Zhou J, Li L. Stimulus-responsive hydrogels as Drug Supply techniques for irritation focused remedy. Adv Sci (Weinh) 2023:e2306152.

  • Shi J, Yu L, Ding J. PEG-based thermosensitive and biodegradable hydrogels. Acta Biomater. 2021;128:42–59.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Zhang Y, Gao C, Li X, Xu C, Zhang Y, Solar Z, Liu Y, Gao J. Thermosensitive methyl cellulose-based injectable hydrogels for post-operation anti-adhesion. Carbohydr Polym. 2014;101:171–8.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Yang B, Gong C, Zhao X, Zhou S, Li Z, Qi X, Zhong Q, Luo F, Qian Z. Stopping postoperative belly adhesions in a rat mannequin with PEG-PCL-PEG hydrogel. Int J Nanomed. 2012;7:547–57.

    CAS 

    Google Scholar
     

  • Shi H, Zhu Y, Xing C, Li S, Bao Z, Lei L, Lin D, Wang Y, Chen H, Xu X. An injectable thermosensitive hydrogel for twin supply of diclofenac and avastin(R) to successfully suppress inflammatory corneal neovascularization. Int J Pharm. 2022;625:122081.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Zhang Z, Ni J, Chen L, Yu L, Xu J, Ding J. Biodegradable and thermoreversible PCLA-PEG-PCLA hydrogel as a barrier for prevention of post-operative adhesion. Biomaterials. 2011;32:4725–36.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Wang J, Hu R, Xing Q, Feng X, Jiang X, Xu Y, et al. Exosomes derived from umbilical twine mesenchymal stem cells alleviate mifepristone-induced human endometrial stromal cell damage. Stem Cells Int. 2020;2020:6091269.

  • Kim YY, Choi BB, Lim JW, Kim YJ, Kim SY, Ku SY. Environment friendly manufacturing of murine uterine injury mannequin. Tissue Eng Regen Med. 2019;16:119–29.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Xiao L, Track Y, Huang W, Yang S, Fu J, Feng X, Zhou M. Expression of SOX2, NANOG and OCT4 in a mouse mannequin of lipopolysaccharide-induced acute uterine damage and intrauterine adhesions. Reprod Biol Endocrinol. 2017;15:14.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang Y, Wang Y, Wu Y, Wang Y. Dulaglutide ameliorates Intrauterine Adhesion by suppressing irritation and epithelial-mesenchymal transition through inhibiting the TGF-beta/Smad2 signaling pathway. Prescription drugs (Basel) 2023, 16.

  • Chen R, Kang R, Tang D. The mechanism of HMGB1 secretion and launch. Exp Mol Med. 2022;54:91–102.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Yao Y, Chen R, Wang G, Zhang Y, Liu F. Exosomes derived from mesenchymal stem cells reverse EMT through TGF-beta1/Smad pathway and promote restore of broken endometrium. Stem Cell Res Ther. 2019;10:225.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Frangogiannis N. Remodeling progress factor-beta in tissue fibrosis. J Exp Med. 2020;217:e20190103.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Feng XH, Derynck R. Specificity and flexibility in tgf-beta signaling via Smads. Annu Rev Cell Dev Biol. 2005;21:659–93.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Klingberg F, Hinz B, White ES. The myofibroblast matrix: implications for tissue restore and fibrosis. J Pathol. 2013;229:298–309.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Shinde AV, Humeres C, Frangogiannis NG. The function of alpha-smooth muscle actin in fibroblast-mediated matrix contraction and reworking. Biochim Biophys Acta Mol Foundation Dis. 2017;1863:298–309.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Wynn TA, Ramalingam TR. Mechanisms of fibrosis: therapeutic translation for fibrotic illness. Nat Med. 2012;18:1028–40.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Paiva P, Lockhart MG, Girling JE, Olshansky M, Woodrow N, Marino JL, Hickey M, Rogers PA. Identification of genes differentially expressed in menstrual breakdown and restore. Mol Hum Reprod. 2016;22:898–912.

    PubMed 
    CAS 

    Google Scholar
     

  • Evans J, Salamonsen LA, Winship A, Menkhorst E, Nie G, Gargett CE, Dimitriadis E. Fertile floor: human endometrial programming and classes in well being and illness. Nat Rev Endocrinol. 2016;12:654–67.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Eming SA, Wynn TA, Martin P. Irritation and metabolism in tissue restore and regeneration. Science. 2017;356:1026–30.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Riau AK, Ong HS, Yam GHF, Mehta JS. Sustained Supply System for Stem Cell-Derived exosomes. Entrance Pharmacol. 2019;10:1368.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Zhao J, Ding Y, He R, Huang Ok, Liu L, Jiang C, Liu Z, Wang Y, Yan X, Cao F, et al. Dose-effect relationship and molecular mechanism by which BMSC-derived exosomes promote peripheral nerve regeneration after crush damage. Stem Cell Res Ther. 2020;11:360.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Zou J, Yang W, Cui W, Li C, Ma C, Ji X, Hong J, Qu Z, Chen J, Liu A, Wu H. Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive supplies in tendon-bone therapeutic. J Nanobiotechnol. 2023;21:14.

    Article 
    CAS 

    Google Scholar
     

  • Mondal J, Pillarisetti S, Junnuthula V, Saha M, Hwang SR, Park IK, Lee YK. Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic functions. J Management Launch. 2023;353:1127–49.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Haraszti RA, Miller R, Stoppato M, Sere YY, Coles A, Didiot MC, Wollacott R, Sapp E, Dubuke ML, Li X, et al. Exosomes produced from 3D cultures of MSCs by tangential Circulate Filtration Present Larger Yield and Improved Exercise. Mol Ther. 2018;26:2838–47.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Hu N, Cai Z, Jiang X, Wang C, Tang T, Xu T, Chen H, Li X, Du X, Cui W. Hypoxia-pretreated ADSC-derived exosome-embedded hydrogels promote angiogenesis and speed up diabetic wound therapeutic. Acta Biomater. 2023;157:175–86.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Pan W, Chen H, Wang A, Wang F, Zhang X. Challenges and techniques: scalable and environment friendly manufacturing of mesenchymal stem cells-derived exosomes for cell-free remedy. Life Sci. 2023;319:121524.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Liang G, Zhu Y, Ali DJ, Tian T, Xu H, Si Ok, Solar B, Chen B, Xiao Z. Engineered exosomes for focused co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon most cancers. J Nanobiotechnol. 2020;18:10.

    Article 
    CAS 

    Google Scholar
     

  • Wang B, Zhang A, Wang H, Klein JD, Tan L, Wang ZM, Du J, Naqvi N, Liu BC, Wang XH. miR-26a limits muscle losing and Cardiac fibrosis via exosome-mediated microRNA switch in power kidney illness. Theranostics. 2019;9:1864–77.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Zhu Q, Tang S, Zhu Y, Chen D, Huang J, Lin J. Exosomes Derived from CTF1-Modified bone marrow stem cells promote endometrial regeneration and restore fertility. Entrance Bioeng Biotechnol. 2022;10:868734.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li J, Pan Y, Yang J, Wang J, Jiang Q, Dou H, Hou Y. Tumor necrosis factor-alpha-primed mesenchymal stem cell-derived exosomes promote M2 macrophage polarization through Galectin-1 and modify intrauterine adhesion on a novel murine mannequin. Entrance Immunol. 2022;13:945234.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Li X, Lv HF, Zhao R, Ying MF, Samuriwo AT, Zhao YZ. Latest developments in bio-scaffold supplies as supply methods for therapeutics for endometrium regeneration. Mater As we speak Bio. 2021;11:100101.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Wu F, Lei N, Yang S, Zhou J, Chen M, Chen C, Qiu L, Guo R, Li Y, Chang L. Therapy methods for intrauterine adhesion: give attention to the exosomes and hydrogels. Entrance Bioeng Biotechnol. 2023;11:1264006.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kou L, Jiang X, Xiao S, Zhao YZ, Yao Q, Chen R. Therapeutic choices and drug supply methods for the prevention of intrauterine adhesions. J Management Launch. 2020;318:25–37.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Chen Y, Fei W, Zhao Y, Wang F, Zheng X, Luan X, Zheng C. Sustained supply of 17beta-estradiol by human amniotic extracellular matrix (HAECM) scaffold built-in with PLGA microspheres for endometrium regeneration. Drug Deliv. 2020;27:1165–75.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Xiao B, Yang W, Lei D, Huang J, Yin Y, Zhu Y, You Z, Wang F, Solar S. PGS scaffolds promote the in vivo survival and directional differentiation of bone marrow mesenchymal stem cells restoring the morphology and performance of wounded rat uterus. Adv Healthc Mater. 2019;8:e1801455.

    Article 
    PubMed 

    Google Scholar
     

  • Wang C, Wang M, Xu T, Zhang X, Lin C, Gao W, Xu H, Lei B, Mao C. Engineering Bioactive Self-Therapeutic Antibacterial exosomes Hydrogel for selling Continual Diabetic Wound Therapeutic and Full pores and skin regeneration. Theranostics. 2019;9:65–76.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Fan L, Liu C, Chen X, Zheng L, Zou Y, Wen H, Guan P, Lu F, Luo Y, Tan G, et al. Exosomes-Loaded Electroconductive Hydrogel synergistically promotes tissue restore after spinal twine Damage through Immunoregulation and Enhancement of Myelinated Axon Progress. Adv Sci (Weinh). 2022;9:e2105586.

    Article 
    PubMed 

    Google Scholar
     

  • Ju Y, Hu Y, Yang P, Xie X, Fang B. Extracellular vesicle-loaded hydrogels for tissue restore and regeneration. Mater As we speak Bio. 2023;18:100522.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Li S, Liu J, Liu S, Jiao W, Wang X. Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage damage restore and assuaging osteoarthritis. J Nanobiotechnol. 2021;19:343.

    Article 
    CAS 

    Google Scholar
     

  • Cao H, Duan L, Zhang Y, Cao J, Zhang Ok. Present hydrogel advances in physicochemical and organic response-driven biomedical utility range. Sign Transduct Goal Ther. 2021;6:426.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Conley BM, Yang L, Bhujel B, Luo J, Han I, Lee KB. Growth of a nanohybrid peptide hydrogel for enhanced intervertebral disc restore and regeneration. ACS Nano. 2023;17:3750–64.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Li L, Xiao B, Mu J, Zhang Y, Zhang C, Cao H, Chen R, Patra HK, Yang B, Feng S, et al. A MnO(2) nanoparticle-dotted hydrogel promotes spinal twine restore through regulating reactive oxygen species Microenvironment and synergizing with mesenchymal stem cells. ACS Nano. 2019;13:14283–93.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Li L, Zhang Y, Mu J, Chen J, Zhang C, Cao H, Gao J. Transplantation of human mesenchymal stem-cell-derived exosomes immobilized in an Adhesive Hydrogel for Efficient Therapy of spinal twine Damage. Nano Lett. 2020;20:4298–305.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Wu Z, Bai J, Ge G, Wang T, Feng S, Ma Q, Liang X, Li W, Zhang W, Xu Y, et al. Regulating macrophage polarization in excessive glucose microenvironment utilizing Lithium-modified Bioglass-Hydrogel for Diabetic Bone Regeneration. Adv Healthc Mater. 2022;11:e2200298.

    Article 
    PubMed 

    Google Scholar
     

  • Leave a Reply

    Your email address will not be published. Required fields are marked *