Nanosilicates facilitate periodontal regeneration potential by activating the PI3K-AKT signaling pathway in periodontal ligament cells | Journal of Nanobiotechnology

  • Slots J. Periodontitis: info, fallacies and the longer term. Periodontol 2000. 2017;75:7–23.

  • Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Advantageous DH, Flemmig TF, Garcia R, Giannobile WV, Graziani F, et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World workshop on the classification of Periodontal and Peri-implant illnesses and circumstances. J Clin Periodontol. 2018;45(Suppl 20):S162–70.

    PubMed 

    Google Scholar
     

  • Sculean A, Chapple IL, Giannobile WV. Wound fashions for periodontal and bone regeneration: the function of biologic analysis. Periodontol 2000. 2015;68:7–20.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Venkataiah VS, Handa Ok, Njuguna MM, Hasegawa T, Maruyama Ok, Nemoto E, Yamada S, Sugawara S, Lu L, Takedachi M, et al. Periodontal regeneration by allogeneic transplantation of adipose tissue derived Multi-lineage Progenitor Stem cells in vivo. Sci Rep. 2019;9:921.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sallum EA, Ribeiro FV, Ruiz KS, Sallum AW. Experimental and scientific research on regenerative periodontal remedy. Periodontol 2000. 2019;79:22–55.

    Article 
    PubMed 

    Google Scholar
     

  • Villar CC, Cochran DL. Regeneration of periodontal tissues: guided tissue regeneration. Dent Clin North Am. 2010;54:73–92.

    Article 
    PubMed 

    Google Scholar
     

  • Kao RT, Nares S, Reynolds MA. Periodontal regeneration – intrabony defects: a scientific assessment from the AAP Regeneration Workshop. J Periodontol. 2015;86:S77–104.

    Article 
    PubMed 

    Google Scholar
     

  • Lin Z, Rios HF, Cochran DL. Rising regenerative approaches for periodontal reconstruction: a scientific assessment from the AAP Regeneration Workshop. J Periodontol. 2015;86:S134–152.

    Article 
    PubMed 

    Google Scholar
     

  • Majzoub J, Barootchi S, Tavelli L, Wang CW, Chan HL, Wang HL. Guided tissue regeneration mixed with bone allograft in infrabony defects: scientific outcomes and evaluation of prognostic elements. J Periodontol. 2020;91:746–55.

    Article 
    PubMed 

    Google Scholar
     

  • Lyons JG, Plantz MA, Hsu WK, Hsu EL, Minardi S. Nanostructured Biomaterials for Bone Regeneration. Entrance Bioeng Biotechnol. 2020;8:922.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mostafavi E, Medina-Cruz D, Kalantari Ok, Taymoori A, Soltantabar P, Webster TJ. Electroconductive Nanobiomaterials for tissue Engineering and Regenerative Medication. Bioelectricity. 2020;2:120–49.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Park J, Park S, Kim JE, Jang KJ, Seonwoo H, Chung JH. Enhanced osteogenic differentiation of Periodontal ligament stem cells utilizing a graphene oxide-coated poly(ε-caprolactone) Scaffold. Polym (Basel) 2021, 13.

  • Cui D, Kong N, Ding L, Guo Y, Yang W, Yan F. Ultrathin 2D Titanium Carbide MXene (Ti(3) C(2) T(x)) nanoflakes activate WNT/HIF-1α-Mediated metabolism reprogramming for Periodontal Regeneration. Adv Healthc Mater. 2021;10:e2101215.

    Article 
    PubMed 

    Google Scholar
     

  • Tomás H, Alves CS, Rodrigues J. Laponite®: A key nanoplatform for biomedical purposes? Nanomedicine 2018, 14:2407–20.

  • Gaharwar AK, Cross LM, Peak CW, Gold Ok, Carrow JK, Brokesh A, Singh KA. 2D nanoclay for Biomedical Functions: Regenerative Medication, therapeutic supply, and Additive Manufacturing. Adv Mater. 2019;31:e1900332.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jiang T, Chen G, Shi X, Guo R. Hyaluronic Acid-Adorned Laponite(®) Nanocomposites for Focused Anticancer Drug Supply. Polym (Basel) 2019, 11.

  • Mihaila SM, Gaharwar AK, Reis RL, Khademhosseini A, Marques AP, Gomes ME. The osteogenic differentiation of SSEA-4 sub-population of human adipose derived stem cells utilizing silicate nanoplatelets. Biomaterials. 2014;35:9087–99.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Carrow JK, Cross LM, Reese RW, Jaiswal MK, Gregory CA, Kaunas R, Singh I, Gaharwar AK. Widespread modifications in transcriptome profile of human mesenchymal stem cells induced by two-dimensional nanosilicates. Proc Natl Acad Sci U S A. 2018;115:E3905–13.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Veernala I, Giri J, Pradhan A, Polley P, Singh R, Yadava SK. Impact of Fluoride Doping in Laponite Nanoplatelets on osteogenic differentiation of Human Dental follicle stem cells (hDFSCs). Sci Rep. 2019;9:915.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li T, Liu ZL, Xiao M, Yang ZZ, Peng MZ, Li CD, Zhou XJ, Wang JW. Affect of bone marrow mesenchymal stem cell immunomodulation on the osteogenic results of laponite. Stem Cell Res Ther. 2018;9:100.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Xu X, Xiao L, Xu Y, Zhuo J, Yang X, Li L, Xiao N, Tao J, Zhong Q, Li Y, et al. Vascularized bone regeneration accelerated by 3D-printed nanosilicate-functionalized polycaprolactone scaffold. Regen Biomater. 2021;8:rbab061.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xu X, Zhuo J, Xiao L, Xu Y, Yang X, Li Y, Du Z, Luo Ok. Nanosilicate-Functionalized Polycaprolactone orchestrates Osteogenesis and osteoblast-Induced multicellular interactions for potential endogenous vascularized bone regeneration. Macromol Biosci. 2022;22:e2100265.

    Article 
    PubMed 

    Google Scholar
     

  • Li J, Zhang F, Zhang N, Geng X, Meng C, Wang X, Yang Y. Osteogenic capability and cytotherapeutic potential of periodontal ligament cells for periodontal regeneration in vitro and in vivo. PeerJ. 2019;7:e6589.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • D’Errico JA, Ouyang H, Berry JE, MacNeil RL, Strayhorn C, Imperiale MJ, Harris NL, Goldberg H, Somerman MJ. Immortalized cementoblasts and periodontal ligament cells in tradition. Bone. 1999;25:39–47.

    Article 
    PubMed 

    Google Scholar
     

  • Iwayama T, Iwashita M, Miyashita Ok, Sakashita H, Matsumoto S, Tomita Ok, Bhongsatiern P, Kitayama T, Ikegami Ok, Shimbo T et al. Plap-1 lineage tracing and single-cell transcriptomics reveal mobile dynamics within the periodontal ligament. Improvement 2022, 149.

  • Tour G, Wendel M, Moll G, Tcacencu I. Bone restore utilizing periodontal ligament progenitor cell-seeded constructs. J Dent Res. 2012;91:789–94.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Zheng B, Jiang J, Chen Y, Lin M, Du Z, Xiao Y, Luo Ok, Yan F. Leptin overexpression in bone marrow stromal cells promotes Periodontal Regeneration in a rat mannequin of osteoporosis. J Periodontol. 2017;88:808–18.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Han X, Alu A, Liu H, Shi Y, Wei X, Cai L, Wei Y. Biomaterial-assisted biotherapy: a quick assessment of biomaterials utilized in drug supply, vaccine growth, gene remedy, and stem cell remedy. Bioact Mater. 2022;17:29–48.

    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Isaka J, Ohazama A, Kobayashi M, Nagashima C, Takiguchi T, Kawasaki H, Tachikawa T, Hasegawa Ok. Participation of periodontal ligament cells with regeneration of alveolar bone. J Periodontol. 2001;72:314–23.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Cui D, Chen C, Luo B, Yan F. Inhibiting PHD2 in human periodontal ligament cells through lentiviral vector-mediated RNA interference facilitates cell osteogenic differentiation and periodontal restore. J Leukoc Biol. 2021;110:449–59.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Suo L, Wu H, Wang P, Xue Z, Gao J, Shen J. The advance of periodontal tissue regeneration utilizing a 3D-printed carbon nanotube/chitosan/sodium alginate composite scaffold. J Biomed Mater Res B Appl Biomater. 2023;111:73–84.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Li L, Zhang Y, Wang M, Zhou J, Zhang Q, Yang W, Li Y, Yan F. Gold nanoparticles mixed human β-Defensin 3 Gene-Modified Human Periodontal ligament cells alleviate Periodontal Destruction through the p38 MAPK pathway. Entrance Bioeng Biotechnol. 2021;9:631191.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shi Z, Jia L, Zhang Q, Solar L, Wang X, Qin X, Xia Y. An altered oral microbiota induced by injections of superparamagnetic iron oxide nanoparticle-labeled periodontal ligament stem cells helps periodontal bone regeneration in rats. Bioeng Transl Med. 2023;8:e10466.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Chen X, Liu Y, Miao L, Wang Y, Ren S, Yang X, Hu Y, Solar W. Managed launch of recombinant human cementum protein 1 from electrospun multiphasic scaffold for cementum regeneration. Int J Nanomed. 2016;11:3145–58.

    Article 
    CAS 

    Google Scholar
     

  • Arzate H, Zeichner-David M, Mercado-Celis G. Cementum proteins: function in cementogenesis, biomineralization, periodontium formation and regeneration. Periodontol 2000. 2015;67:211–33.

    Article 
    PubMed 

    Google Scholar
     

  • Liu J, Yang L, Liu Ok, Gao F. Hydrogel scaffolds in bone regeneration: their promising roles in angiogenesis. Entrance Pharmacol. 2023;14:1050954.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Demcisakova Z, Luptakova L, Tirpakova Z, Kvasilova A, Medvecky L, De Spiegelaere W, Petrovova E. Analysis of Angiogenesis in an Acellular Porous Biomaterial primarily based on Polyhydroxybutyrate and Chitosan utilizing the Hen Ex Ovo Chorioallantoic membrane mannequin. Cancers (Basel) 2022, 14.

  • Pizzicannella J, Gugliandolo A, Orsini T, Fontana A, Ventrella A, Mazzon E, Bramanti P, Diomede F, Trubiani O. Engineered Extracellular vesicles from Human Periodontal-Ligament stem cells improve VEGF/VEGFR2 expression throughout bone regeneration. Entrance Physiol. 2019;10:512.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shang L, Liu Z, Ma B, Shao J, Wang B, Ma C, Ge S. Dimethyloxallyl glycine/nanosilicates-loaded osteogenic/angiogenic difunctional fibrous construction for practical periodontal tissue regeneration. Bioact Mater. 2021;6:1175–88.

    PubMed 
    CAS 

    Google Scholar
     

  • Lian M, Solar B, Han Y, Yu B, Xin W, Xu R, Ni B, Jiang W, Hao Y, Zhang X, et al. A low-temperature-printed hierarchical porous sponge-like scaffold that promotes cell-material interplay and modulates paracrine exercise of MSCs for vascularized bone regeneration. Biomaterials. 2021;274:120841.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Qazi TH, Tytgat L, Dubruel P, Duda GN, Van Vlierberghe S, Geissler S. Extrusion printed scaffolds with various pore dimension as modulators of MSC Angiogenic Paracrine results. ACS Biomater Sci Eng. 2019;5:5348–58.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Yang J, Hao X, Li Q, Akpanyung M, Nejjari A, Neve AL, Ren X, Guo J, Feng Y, Shi C, Zhang W. CAGW peptide- and PEG-Modified gene service for selective Gene Supply and Promotion of angiogenesis in HUVECs in vivo. ACS Appl Mater Interfaces. 2017;9:4485–97.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Liu Q, Zhang H, An Y, Zhang Y, He Q, Liu Ok, Xia Q, Zhou H. Xinkeshu tablets promote angiogenesis in zebrafish embryos and human umbilical vein endothelial cells by means of a number of signaling pathways. J Ethnopharmacol. 2023;314:116636.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Iwasaki Ok, Akazawa Ok, Nagata M, Komaki M, Peng Y, Umeda M, Watabe T, Morita I. Angiogenic results of secreted elements from Periodontal Ligament Stem cells. Dent J (Basel) 2021, 9.

  • Nanda SS, Yi DK. Latest advances in synergistic impact of nanoparticles and its Biomedical Software. Int J Mol Sci 2024, 25.

  • Brokesh AM, Cross LM, Kersey AL, Murali A, Richter C, Gregory CA, Singh I, Gaharwar AK. Dissociation of nanosilicates induces downstream endochondral differentiation gene expression program. Sci Adv. 2022;8:eabl9404.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Mousa M, Evans ND, Oreffo ROC, Dawson JI. Clay nanoparticles for regenerative drugs and biomaterial design: a assessment of clay bioactivity. Biomaterials. 2018;159:204–14.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Mousa M, Kim YH, Evans ND, Oreffo ROC, Dawson JI. Monitoring mobile uptake, intracellular trafficking and destiny of nanoclay particles in human bone marrow stromal cells. Nanoscale. 2023;15:18457–72.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Ersahin T, Tuncbag N, Cetin-Atalay R. The PI3K/AKT/mTOR interactive pathway. Mol Biosyst. 2015;11:1946–54.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Pompura SL, Dominguez-Villar M. The PI3K/AKT signaling pathway in regulatory T-cell growth, stability, and performance. J Leukoc Biol 2018.

  • Liu X, Chen M, Luo J, Zhao H, Zhou X, Gu Q, Yang H, Zhu X, Cui W, Shi Q. Immunopolarization-regulated 3D printed-electrospun fibrous scaffolds for bone regeneration. Biomaterials. 2021;276:121037.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Gao S, Chen B, Zhu Z, Du C, Zou J, Yang Y, Huang W, Liao J. PI3K-Akt signaling regulates BMP2-induced osteogenic differentiation of mesenchymal stem cells (MSCs): a transcriptomic panorama evaluation. Stem Cell Res. 2023;66:103010.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Chen J, Liu Z, Zhang H, Yang Y, Zeng H, Zhong R, Lai S, Liao H. YBX1 promotes MSC osteogenic differentiation by activating the PI3K/AKT pathway. Curr Stem Cell Res Ther. 2023;18:513–21.

    Article 
    PubMed 

    Google Scholar
     

  • Zhu B, Wu J, Li T, Liu S, Guo J, Yu Y, Qiu X, Zhao Y, Peng H, Zhang J, et al. A glutathione peroxidase-mimicking Nanozyme exactly alleviates reactive oxygen species and promotes Periodontal Bone Regeneration. Adv Healthc Mater. 2024;13:e2302485.

    Article 
    PubMed 

    Google Scholar
     

  • Padial-Molina M, Rodriguez JC, Volk SL, Rios HF. Standardized in vivo mannequin for finding out novel regenerative approaches for multitissue bone-ligament interfaces. Nat Protoc. 2015;10:1038–49.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Xu T, Xie Ok, Wang C, Ivanovski S, Zhou Y. Immunomodulatory nanotherapeutic approaches for periodontal tissue regeneration. Nanoscale. 2023;15:5992–6008.

    Article 
    PubMed 
    CAS 

    Google Scholar
     

  • Wang S, Wang P, Thompson R, Ostrikov Ok, Xiao Y, Zhou Y. Plasma-activated medium triggers immunomodulation and autophagic exercise for periodontal regeneration. Bioeng Transl Med. 2023;8:e10528.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar
     

  • Polimeni G, Xiropaidis AV, Wikesjö UM. Biology and rules of periodontal wound therapeutic/regeneration. Periodontol 2000. 2006;41:30–47.

    Article 
    PubMed 

    Google Scholar
     

  • Leave a Reply

    Your email address will not be published. Required fields are marked *