Huang, J. et al. A single peptide-major histocompatibility complicated ligand triggers digital cytokine secretion in CD4(+) T cells. Immunity 39, 846–857 (2013).
Sasmal, D. Ok. et al. TCR–pMHC bond conformation controls TCR ligand discrimination. Cell Mol. Immunol. 17, 203–217 (2020).
Kim, S. T. et al. The αβ T cell receptor is an anisotropic mechanosensor. J. Biol. Chem. 284, 31028–31037 (2009).
Lee, M. S. et al. A mechanical swap {couples} T cell receptor triggering to the cytoplasmic juxtamembrane areas of CD3ζζ. Immunity 43, 227–239 (2015).
Liu, B. et al. Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling. Cell 157, 357–368 (2014).
Feng, Y. et al. Mechanosensing drives acuity of αβ T cell recognition. Proc. Natl Acad. Sci. USA 114, E8204–E8213 (2017).
Zhang, Y. et al. DNA-based digital rigidity probes reveal integrin forces throughout early cell adhesion. Nat. Commun. 5, 5167 (2014).
Stabley, D. R. et al. Visualizing mechanical rigidity throughout membrane receptors with a fluorescent sensor. Nat. Strategies 9, 64–67 (2011).
Chang, A. C. et al. Single molecule drive measurements in dwelling cells reveal a minimally tensioned integrin state. ACS Nano 10, 10745–10752 (2016).
Hong, J. et al. A TCR mechanotransduction signaling loop induces damaging choice within the thymus. Nat. Immunol. 19, 1379–1390 (2018).
Liu, Y. et al. DNA-based nanoparticle rigidity sensors reveal that T cell receptors transmit outlined pN forces to their antigens for enhanced constancy. Proc. Natl Acad. Sci. USA 113, 5610–5615 (2016).
Wang, M. S. et al. Mechanically lively integrins goal lytic secretion on the immune synapse to facilitate mobile cytotoxicity. Nat. Commun. 13, 3222 (2022).
Ma, V. P. et al. Ratiometric rigidity probes for mapping receptor forces and clustering at intermembrane junctions. Nano Lett. 16, 4552–4559 (2016).
Gohring, J. et al. Temporal evaluation of T cell receptor-imposed forces by way of quantitative single molecule FRET measurements. Nat. Commun. 12, 2502 (2021).
Nowosad, C. R. et al. Germinal heart B cells acknowledge antigen via a specialised immune synapse structure. Nat. Immunol. 17, 870–877 (2016).
Sage, P. T. et al. Antigen recognition is facilitated by invadosome-like protrusions fashioned by reminiscence/effector T cells. J. Immunol. 188, 3686–3699 (2012).
Aramesh, M. et al. Functionalized bead assay to measure three-dimensional traction forces throughout T cell activation. Nano Lett. 21, 507–514 (2021).
Wahl, A. et al. Biphasic mechanosensitivity of T cell receptor-mediated spreading of lymphocytes. Proc. Natl Acad. Sci. USA 116, 5908–5913 (2019).
Saitakis, M. et al. Totally different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity. eLife 6, e23190 (2017).
Hellmeier, J. et al. DNA origami show the distinctive stimulatory energy of single pMHCs as T cell antigens. Proc. Natl Acad. Sci. USA 118, e2016857118 (2021).
Dong, R. et al. DNA origami patterning of artificial T cell receptors reveals spatial management of the sensitivity and kinetics of sign activation. Proc. Natl Acad. Sci. USA 118, e2109057118 (2021).
Fang, T. et al. Spatial regulation of T cell signaling by programmed death-ligand 1 on wireframe DNA origami flat sheets. ACS Nano 15, 3441–3452 (2021).
Damjanovich, S. et al. Distribution and mobility of murine histocompatibility H-2Kokay antigen within the cytoplasmic membrane. Proc. Natl Acad. Sci. USA 80, 5985–5989 (1983).
Glazier, R. et al. DNA mechanotechnology reveals that integrin receptors apply pN forces in podosomes on fluid substrates. Nat. Commun. 10, 4507 (2019).
Monks, C. R. F. et al. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395, 82–86 (1998).
James, J. R. et al. Biophysical mechanism of T cell receptor triggering in a reconstituted system. Nature 487, 64–69 (2012).
Jenkins, E. et al. Antigen discrimination by T cells depends on size-constrained microvillar contact. Nat. Commun. 14, 1611 (2023).
Cai, E. et al. Visualizing dynamic microvillar search and stabilization throughout ligand detection by T cells. Science 356, eaal3118 (2017).
Hatch, Ok. et al. Demonstration that the shear drive required to separate brief double-stranded DNA doesn’t enhance considerably with sequence size for sequences longer than 25 base pairs. Phys. Rev. E 78, 011920 (2008).
Woodside, M. T. et al. Nanomechanical measurements of the sequence-dependent folding landscapes of single nucleic acid hairpins. Proc. Natl Acad. Sci. USA 103, 6190–6195 (2006).
Ma, R. et al. DNA probes that retailer mechanical data reveal transient piconewton forces utilized by T cells. Proc. Natl Acad. Sci. USA 116, 16949–16954 (2019).
Glazier, R. et al. Spectroscopic evaluation of a library of DNA rigidity probes for mapping mobile forces at fluid interfaces. ACS Appl. Mater. Interfaces 13, 2145–2164 (2021).
Wang, X. et al. Defining single molecular forces required to activate integrin and notch signaling. Science 340, 991–994 (2013).
Whitton, J. L. et al. Purposeful avidity maturation of CD8+ T cells with out collection of increased affinity TCR. Nat. Immunol. 2, 711–717 (2001).
Thauland, T. J. et al. Cytoskeletal adaptivity regulates T cell receptor signaling. Sci. Sign 10, eaah3737 (2017).
Fletcher, D. A. et al. Cell mechanics and the cytoskeleton. Nature 463, 485–492 (2010).
Borroto, A. et al. First-in-class inhibitor of the T cell receptor for the remedy of autoimmune ailments. Sci. Transl. Med. 8, 370ra184 (2016).
Barda-Saad, M. et al. Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton. Nat. Immunol. 6, 80–89 (2005).
Su, X. et al. Part separation of signaling molecules promotes T cell receptor sign transduction. Science 352, 595–599 (2016).
Al-Aghbar, M. A. et al. The interaction between membrane topology and mechanical forces in regulating T cell receptor exercise. Commun. Biol. 5, 40 (2022).
Allard, J. F. et al. Mechanical modulation of receptor–ligand interactions at cell–cell interfaces. Biophys. J. 102, 1265–1273 (2012).
Cespedes, P. F. et al. T cell trans-synaptic vesicles are distinct and carry higher effector content material than constitutive extracellular vesicles. Nat. Commun. 13, 3460 (2022).
Olden, B. R. et al. Cell-templated silica microparticles with supported lipid bilayers as synthetic antigen-presenting cells for T cell activation. Adv. Well being. Mater. 8, e1801188 (2019).
Zhao, X. et al. Tuning T cell receptor sensitivity via catch bond engineering. Science 376, eabl5282 (2022).
Feng, Y. et al. A bead-based methodology for high-throughput mapping of the sequence- and force-dependence of T cell activation. Nat. Strategies 19, 1295–1305 (2022).
Grakoui, A. et al. The immunological synapse—a molecular machine controlling T cell activation. Science 285, 221–227 (1999).
Kumari, S. et al. T cell antigen receptor activation and actin cytoskeleton transforming. Biochim. Biophys. Acta 1838, 546–556 (2014).
Ge, Z. et al. Programming cell–cell communications with engineered cell origami clusters. J. Am. Chem. Soc. 142, 8800–8808 (2020).
Zhao, W. et al. Cell-surface sensors for real-time probing of mobile environments. Nat. Nanotechnol. 6, 524–531 (2011).
Liu, Y. et al. The consequences of overhang placement and multivalency on cell labeling by DNA origami. Nanoscale 13, 6819–6828 (2021).
Akbari, E. et al. Engineering cell floor perform with DNA origami. Adv. Mater. 29, 1703632 (2017).
Lei, Ok. et al. Most cancers-cell stiffening by way of ldl cholesterol depletion enhances adoptive T cell immunotherapy. Nat. Biomed. Eng. 5, 1411–1425 (2021).
Bashour, Ok. T. et al. CD28 and CD3 have complementary roles in T cell traction forces. Proc. Natl Acad. Sci. USA 111, 2241–2246 (2014).
Cai, H. et al. Full management of ligand positioning reveals spatial thresholds for T cell receptor triggering. Nat. Nanotechnol. 13, 610–617 (2018).
Deeg, J. et al. T cell activation is set by the variety of introduced antigens. Nano Lett. 13, 5619–5626 (2013).
Amiri, S. et al. Intracellular rigidity sensor reveals mechanical anisotropy of the actin cytoskeleton. Nat. Commun. 14, 8011 (2023).
Galush, W. J. et al. Quantitative fluorescence microscopy utilizing supported lipid bilayer requirements. Biophys. J. 95, 2512–2519 (2008).