MXene-based architectures have paved the best way in varied fields, notably in healthcare space, owing to their outstanding physiochemical and electromagnetic traits. Furthermore, the modification of MXene buildings and their mixture with polymeric networks have gained appreciable prominence to additional develop their options. The mixture of electrospun fibers with MXenes could be promising on this regard since electrospinning is a well-established method that’s now being directed towards industrial biomedical purposes. The introduction of MXenes into electrospun fibrous frameworks has highlighted outcomes in varied biomedical purposes, together with most cancers remedy, managed drug supply, antimicrobial targets, sensors, and tissue engineering. Correspondingly, this evaluation describes the employed methods for the preparation of electrospun configurations in tandem with MXene nanostructures with outstanding traits. Subsequent, the benefits of MXene-decorated electrospun fibers to be used in biomedical purposes are comprehensively mentioned. Based on the investigations, wealthy floor purposeful teams, hydrophilicity, massive floor space, photothermal options, and antimicrobial and antibacterial actions of MXenes may synergize the efficiency of electrospun layers to engineer versatile biomedical targets. Furthermore, the way forward for this path is clarified to fight the challenges associated to the electrospun fibers embellished with MXene nanosheets.