With distinctive benefits spanning wonderful flexibility, wealthy bodily properties, robust electrostatic tunability, dangling-bond-free floor, and ease of integration, 2D layered supplies (2DLMs) have demonstrated large potential for photodetection. Nonetheless, to this point, many of the analysis enthusiasm has been merely centered on growing novel prototype gadgets. Up to now few years, researchers have additionally been dedicated to growing numerous downstream purposes based mostly on 2DLM photodetectors to contribute to selling them from elementary analysis to sensible commercialization, and intensive accomplishments have been realized. Despite the exceptional developments, these fascinating analysis findings are comparatively scattered. Thus far, there’s nonetheless an absence of a scientific and profound summarization relating to this fast-evolving area. This isn’t useful to researchers, particularly researchers simply coming into this analysis area, who need to have a fast, well timed, and complete inspection of this fascinating area. To handle this subject, on this assessment, the rising downstream purposes of 2DLM photodetectors in intensive fields, together with imaging, well being monitoring, goal monitoring, optoelectronic logic operation, ultraviolet monitoring, optical communications, computerized driving, and acoustic sign detection, have been systematically summarized, with the concentrate on the underlying working mechanisms. On the finish, the continued challenges of this quickly progressing area are recognized, and the potential schemes to deal with them are envisioned, which purpose at navigating the long run exploration in addition to absolutely exerting the pivotal roles of 2DLMs in direction of the sensible optoelectronic business.